Mebendazole Induces Apoptosis via Bcl-2 Inactivation in Chemoresistant Melanoma Cells
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منابع مشابه
Chemoresistant Melanoma Cells Mebendazole Induces Apoptosis via Bcl-2 Inactivation in
Most metastatic melanoma patients fail to respond to available therapy, underscoring the need for novel approaches to identify new effective treatments. In this study, we screened 2,000 compounds from the Spectrum Library at a concentration of 1 Mmol/L using two chemoresistant melanoma cell lines (M-14 and SK-Mel-19) and a spontaneously immortalized, nontumorigenic melanocyte cell line (melan-a...
متن کاملMebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.
Most metastatic melanoma patients fail to respond to available therapy, underscoring the need for novel approaches to identify new effective treatments. In this study, we screened 2,000 compounds from the Spectrum Library at a concentration of 1 micromol/L using two chemoresistant melanoma cell lines (M-14 and SK-Mel-19) and a spontaneously immortalized, nontumorigenic melanocyte cell line (mel...
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Objective: To investigate the impact of a Croton tiglium extract on cellular proliferation and apoptosis in a nonsmall cell lung cancer cell line (A549) in vitro. Methods: A Croton tiglium seed methanol extract was prepare and assessed for effects on A549 cells regarding cellular proliferation, apoptotic rates, and expression of apoptosis related genes and proteins using real-time PCR and immun...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2008
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-07-2159